Antituberculosis treatment-induced hepatotoxicity: role of predictive factors.
نویسندگان
چکیده
منابع مشابه
Antituberculosis treatment-induced hepatotoxicity: role of predictive factors.
Antituberculosis drug-induced hepatotoxicity is quite common. However, factors predicting its development are still controversial. The objective of the present study was to evaluate the role of certain factors (age and sex of the patient, alcoholism, chronic liver disease, hepatitis B virus carrier status, acetylator status, nutritional status and antituberculosis treatment (ATT) regimen) in pr...
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BACKGROUND & OBJECTIVES Antituberculosis (anti-TB) drug induced hepatotoxicity (DIH) is the most common side effect leading to interruption of therapy. Wide variations have been found in the reported incidence of hepatotoxicity during short-course chemotherapy. Several risk factors for hepatotoxicity have been suggested in previous studies. We undertook a prospective case-control study to asses...
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The aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Iranian pulmonary tuberculosis patients. Acetylating phenotypes was studied in 50 Iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-Isoniazid to Isoniazid. The association between hepatotoxicity and the n-acetyltransferas...
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commonly encountered adverse effect withantituberculosis treatment.6-8 Recent developments especially in the field of molecular biology have expanded our views on the understanding of drug-induced liver damage. 9,10 In this paper, we have attempted to summarise the current understanding of the pathogenetic mechanismsof DIH as it has been viewed from the laboratory bench and the bedsideimplicati...
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The aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Iranian pulmonary tuberculosis patients. Acetylating phenotypes was studied in 50 Iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-Isoniazid to Isoniazid. The association between hepatotoxicity and the n-acetyltransferas...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1995
ISSN: 0032-5473
DOI: 10.1136/pgmj.71.836.359